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- Presents novel approaches in the diagnosis and treatment of tumors of neuroendocrine origin
- Examines strategies in the treatment of NEN according to therapy responsivity
- Explores new perspectives in NEN treatment according to their biology and origin
This book provides the most recent update on the management of neuroendocrine neoplasia (NEN), a term covering all tumors of various organs and/or with a particular histology, including MEN (multiple endocrine neoplasia) related tumors, MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasms), NEC (neuroendocrine carcinoma) and Merkel’s carcinoma. NENs are heterogeneous in their biology, clinical presentation and prognosis, showing a great variability in aggressiveness and therapy response. As a result, their treatment is based on a large spectrum of options. The standard therapies are surgery in early disease, various loco-regional procedures in certain conditions and mostly of a palliative nature in metastatic disease. At present, thanks to our increased understanding of molecular signaling pathways, several pharmacological approaches can be used in patients with advanced NENs. Somatostatin analogs display both anti-tumor effects and symptom control. Novel peptide-radio-receptor treatment (PRRT) is used in patients with well differentiated tumors. The agents targeting angiogenesis and/or PI3K/AKT/mTOR pathway, alone or in combination with analogues, have provided encouraging results in advanced disease. The first part of the book focuses on the history, epidemiology and the most relevant scientific achievements, covering the discoveries in genetic and molecular biology, the endoscopic techniques with guided biopsy, and the metabolic imaging with hybrid PET/CT and MRI/CT. It particularly highlights the emerging strategies in therapy, surgery and mini-invasive surgery as well as loco-regional and systemic treatments, including targeted therapy and/or biological therapies. The second part then explores the management of NENs of various anatomical origins and/or with peculiar biology. It describes the range of the current options and the most relevant results from the clinical trials. This informative book provides valuable insigh Table of Contents- History of Neuroendocrine Neoplasia
- Epidemiology of Neuroendocrine Neoplasms
- New Concepts in Pathology
- Molecular Biology of Neuroendocrine Tumors
- Circulating Biochemical Markers of Gastro-Entero-Pancreatic (GEP) Neuroendocrine Neoplasms (NENs)
- Advances in Diagnostic Imaging
- Treatment of NET-Related Symptoms
- New Surgical Strategies
- New Approaches in Medical Therapies
- Locoregional Therapies of NEN
- Radioreceptor Therapy
- NETs of the Lung
- Gastric Neuroendocrine Tumors
- Treatment of Pancreatic Neuroendocrine Tumors
- Treatment of Intestinal NETs (Including Appendix)
- Treatment of NETs from Rare Origin
- Neuroendocrine Neoplasms with Peculiar Biology and Features: MEN1, MEN2A, MEN2B, MEN4, VHL, NF1
- Mixed Neuroendocrine and Non-neuroendocrine Neoplasms (Mi NEN)
- Merkel Cell Carcinoma
- Therapy in Poorly Differentiated Neuroendocrine Neoplasms (NEN G3)
- Conclusions: NEN Management Today and Looking at the Future
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